3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:(Formula I should be inserted here) where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herei...
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| creator | ZHENG, XIAOZHANG MILLAN, DAVID S MARTIN, MATTHEW W HAN, BINGSONG THOMASON, JENNIFER R DAVIS, HEATHER NG, PUI YEE LANCIA, DAVID LIU, CUIXIAN RUDNITSKAYA, ALEKSANDRA ZABLOCKI, MARY-MARGARET |
| description | The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:(Formula I should be inserted here) where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
La présente invention concerne des inhibiteurs d'histone désacétylases zinc-dépendantes (HDAC) utiles dans le traitement de maladies ou de troubles associés à une HDAC, par exemple, HDAC6, de formule I dans laquelle R, L, X1, X2, X3, X4, Y1, Y2, Y3, et Y4 sont tels que décrits dans la description. |
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La présente invention concerne des inhibiteurs d'histone désacétylases zinc-dépendantes (HDAC) utiles dans le traitement de maladies ou de troubles associés à une HDAC, par exemple, HDAC6, de formule I dans laquelle R, L, X1, X2, X3, X4, Y1, Y2, Y3, et Y4 sont tels que décrits dans la description.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231212&DB=EPODOC&CC=CA&NR=2990165C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231212&DB=EPODOC&CC=CA&NR=2990165C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHENG, XIAOZHANG</creatorcontrib><creatorcontrib>MILLAN, DAVID S</creatorcontrib><creatorcontrib>MARTIN, MATTHEW W</creatorcontrib><creatorcontrib>HAN, BINGSONG</creatorcontrib><creatorcontrib>THOMASON, JENNIFER R</creatorcontrib><creatorcontrib>DAVIS, HEATHER</creatorcontrib><creatorcontrib>NG, PUI YEE</creatorcontrib><creatorcontrib>LANCIA, DAVID</creatorcontrib><creatorcontrib>LIU, CUIXIAN</creatorcontrib><creatorcontrib>RUDNITSKAYA, ALEKSANDRA</creatorcontrib><creatorcontrib>ZABLOCKI, MARY-MARGARET</creatorcontrib><title>3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS</title><description>The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:(Formula I should be inserted here) where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
La présente invention concerne des inhibiteurs d'histone désacétylases zinc-dépendantes (HDAC) utiles dans le traitement de maladies ou de troubles associés à une HDAC, par exemple, HDAC6, de formule I dans laquelle R, L, X1, X2, X3, X4, Y1, Y2, Y3, et Y4 sont tels que décrits dans la description.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAy1nUMivTRNdF19PV08dd18nSOdPbxdFaINtEx1TGI9Yh0CfKPAMo5Kzg6e7oEKzgGK3i4ODorePp5eDp5hvgHBfMwsKYl5hSn8kJpbgZ5N9cQZw_d1IL8-NTigsTk1LzUknhnRyNLSwNDM1NnY8IqAPTvKZI</recordid><startdate>20231212</startdate><enddate>20231212</enddate><creator>ZHENG, XIAOZHANG</creator><creator>MILLAN, DAVID S</creator><creator>MARTIN, MATTHEW W</creator><creator>HAN, BINGSONG</creator><creator>THOMASON, JENNIFER R</creator><creator>DAVIS, HEATHER</creator><creator>NG, PUI YEE</creator><creator>LANCIA, DAVID</creator><creator>LIU, CUIXIAN</creator><creator>RUDNITSKAYA, ALEKSANDRA</creator><creator>ZABLOCKI, MARY-MARGARET</creator><scope>EVB</scope></search><sort><creationdate>20231212</creationdate><title>3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS</title><author>ZHENG, XIAOZHANG ; MILLAN, DAVID S ; MARTIN, MATTHEW W ; HAN, BINGSONG ; THOMASON, JENNIFER R ; DAVIS, HEATHER ; NG, PUI YEE ; LANCIA, DAVID ; LIU, CUIXIAN ; RUDNITSKAYA, ALEKSANDRA ; ZABLOCKI, MARY-MARGARET</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2990165C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHENG, XIAOZHANG</creatorcontrib><creatorcontrib>MILLAN, DAVID S</creatorcontrib><creatorcontrib>MARTIN, MATTHEW W</creatorcontrib><creatorcontrib>HAN, BINGSONG</creatorcontrib><creatorcontrib>THOMASON, JENNIFER R</creatorcontrib><creatorcontrib>DAVIS, HEATHER</creatorcontrib><creatorcontrib>NG, PUI YEE</creatorcontrib><creatorcontrib>LANCIA, DAVID</creatorcontrib><creatorcontrib>LIU, CUIXIAN</creatorcontrib><creatorcontrib>RUDNITSKAYA, ALEKSANDRA</creatorcontrib><creatorcontrib>ZABLOCKI, MARY-MARGARET</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHENG, XIAOZHANG</au><au>MILLAN, DAVID S</au><au>MARTIN, MATTHEW W</au><au>HAN, BINGSONG</au><au>THOMASON, JENNIFER R</au><au>DAVIS, HEATHER</au><au>NG, PUI YEE</au><au>LANCIA, DAVID</au><au>LIU, CUIXIAN</au><au>RUDNITSKAYA, ALEKSANDRA</au><au>ZABLOCKI, MARY-MARGARET</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS</title><date>2023-12-12</date><risdate>2023</risdate><abstract>The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:(Formula I should be inserted here) where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
La présente invention concerne des inhibiteurs d'histone désacétylases zinc-dépendantes (HDAC) utiles dans le traitement de maladies ou de troubles associés à une HDAC, par exemple, HDAC6, de formule I dans laquelle R, L, X1, X2, X3, X4, Y1, Y2, Y3, et Y4 sont tels que décrits dans la description.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS |
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