3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS

3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS

The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:(Formula I should be inserted here) where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herei...

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Hauptverfasser: ZHENG, XIAOZHANG, MILLAN, DAVID S, MARTIN, MATTHEW W, HAN, BINGSONG, THOMASON, JENNIFER R, DAVIS, HEATHER, NG, PUI YEE, LANCIA, DAVID, LIU, CUIXIAN, RUDNITSKAYA, ALEKSANDRA, ZABLOCKI, MARY-MARGARET
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:(Formula I should be inserted here) where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein. La présente invention concerne des inhibiteurs d'histone désacétylases zinc-dépendantes (HDAC) utiles dans le traitement de maladies ou de troubles associés à une HDAC, par exemple, HDAC6, de formule I dans laquelle R, L, X1, X2, X3, X4, Y1, Y2, Y3, et Y4 sont tels que décrits dans la description.