TAXANE PARTICLES AND THEIR USE

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30...

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Bibliographische Detailangaben
Hauptverfasser:	FISCHER, JULIA K, FARTHING, JOSEPH, SITTENAUER, JAKE, CAMPBELL, SAMUEL, MCCLOREY, MATTHEW, BALTEZOR, MICHAEL, ESPINOSA, JAHNA, WILLIAMS, MARK D, CLAPP, GARRY E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided. La présente invention concerne des compositions qui comprennent au moins 95 % en poids d'un taxane, ou son sel pharmaceutiquement acceptable, les particules présentant une densité en vrac moyenne comprise entre environ 0,050 g/cm3 et environ 0,15 g/cm3, et/ou une surface spécifique d'au moins 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, ou 35 m2/g. L'invention a également trait à des procédés de fabrication et d'utilisation de ces compositions.