METHODS FOR IDENTIFYING COMPOUNDS THAT BIND TO TUMOUR NECROSIS FACTOR SUPERFAMILY MEMBERS AND MODULATE SIGNALLING OF THE RECEPTOR

METHODS FOR IDENTIFYING COMPOUNDS THAT BIND TO TUMOUR NECROSIS FACTOR SUPERFAMILY MEMBERS AND MODULATE SIGNALLING OF THE RECEPTOR

It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. Anew assay for identifying compounds with this mechanism of action is also disclosed. Il a été démon...

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Bibliographische Detailangaben
Hauptverfasser: O'CONNELL, JAMES PHILIP, RAPECKI, STEPHEN EDWARD, WARRELLOW, GRAHAM JOHN, PORTER, JOHN ROBERT, NORMAN, TIMOTHY JOHN, KROEPLIEN, BORIS, LAWSON, ALASTAIR
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Zusammenfassung:It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. Anew assay for identifying compounds with this mechanism of action is also disclosed. Il a été démontré que certains composés se lient au TNF et stabilisent une conformation du TNF trimérique qui se lie au récepteur TNF. En conséquence, ces composés peuvent être utilisés en tant que modulateurs du TNF. L'invention concerne également un nouveau dosage permettant d'identifier des composés ayant ce mécanisme d'action.