MODULATION OF MEMBERS OF THE TNF SUPERFAMILY

The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy. L'invention se rapporte au...

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Bibliographische Detailangaben
Hauptverfasser:	MCMILLAN, DAVID JAMES, O'CONNELL, JAMES PHILIP, RAPECKI, STEPHEN EDWARD, WARRELLOW, GRAHAM JOHN, PORTER, JOHN ROBERT, NORMAN, TIMOTHY JOHN, ALEXANDER, RIKKI PETER, BROOKINGS, DANIEL CHRISTOPHER, KROEPLIEN, BORIS, LAWSON, ALASTAIR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy. L'invention se rapporte au domaine de la signalisation du TNF. Des composés aptes à moduler la signalisation de trimères de TNF par l'intermédiaire de récepteurs ont été identifiés. L'invention concerne donc des procédés pour identifier ces composés. Les composés eux-mêmes présentent une utilité thérapeutique.