CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of Formula (I-A), including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositio...

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Bibliographische Detailangaben
Hauptverfasser: HU, LILI, DEMIN, SAMUEL DOMINIQUE, RABOISSON, PIERRE JEAN-MARIE BERNARD, PIETERS, SERGE MARIA ALOYSIUS, GROSSE, SANDRINE CELINE, LAST, STEFAAN JULIEN, VANDYCK, KOEN, HACHE, GEERWIN YVONNE PAUL, ROMBOUTS, GEERT, VENDEVILLE, SANDRINE MARIE HELENE, VERSCHUEREN, WIM GASTON
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Inhibitors of HBV replication of Formula (I-A), including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy. L'invention concerne des inhibiteurs de réplication du VHB de Formule (I-A), y compris leurs formes isomères stéréochimiques, ainsi que leurs sels, hydrates, solvates de ceux-ci, où Ra à Rd, et R1 à R8 sont tels que définis dans la description. Des procédés de préparation desdits composés, des compositions pharmaceutiques les contenant et leur utilisation, seules ou en combinaison avec d'autres inhibiteurs du VHB, à titre de traitement contre l'hépatite B, sont en outre décrits.