NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The 5 invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or preven...

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Bibliographische Detailangaben
Hauptverfasser: MCALPINE, INDRAWAN JAMES, MADERNA, ANDREAS, CROSIGNANI, STEFANO, NINKOVIC, SACHA, COLLINS, MICHAEL RAYMOND, WYTHES, MARTIN, SCALES, STEPHANIE ANNE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The 5 invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also 10 relates to a process for manufacturing compounds of Formula I. Cette invention concerne un composé de Formule I, ou des énantiomères, des sels ou des solvates de ceux-ci pharmaceutiquement acceptables. L'invention concerne en outre l'utilisation des composés de Formule I à titre d'inhibiteurs de TDO2. L'utilisation des composés de Formule I pour traiter et/ou prévenir le cancer, des troubles neurodégénératifs tels que la maladie de Parkinson, la maladie d'Alzheimer et la maladie de Huntington, des infections virales chroniques telles que les infections à VHC et VIH, la dépression et l'obésité est en outre décrite. L'invention concerne également un procédé de fabrication des composés de Formule I.