PORCINE EPIDEMIC DIARRHEA VIRUS STRAINS AND IMMUNOGENIC COMPOSITIONS THEREFROM

The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus ("PEDV"), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines pr...

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Bibliographische Detailangaben
Hauptverfasser:	VALDEZ, WALTER, MADSON, DARIN, CHEN, QI, GAUGER, PHILLIP, CALVERT, JAY GREGORY, ZHANG, JIANQIANG, STOEVA, MIRA IVANOVA, BANDRICK, MEGGAN, THOMPSON, JAMES RICHARD, HARDHAM, JOHN MORGAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus ("PEDV"), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture. La présente invention concerne de nouvelles séquences de nucléotides et d'acides aminés du virus de la diarrhée épidémique porcine (VDEP), comprenant de nouveaux génotypes de celui-ci, utiles dans la préparation de vaccins destinés au traitement et à la prévention de maladies chez le porc et d'autres animaux. Les vaccins obtenus selon la pratique de la présente invention sont efficaces contre de multiples isolats et génotypes du VDEP porcin. La présente invention concerne également des anticorps monoclonaux et polyclonaux diagnostiques et thérapeutiques, ainsi que des clones infectieux utiles pour la propagation du virus et la préparation de vaccins. Des aspects particulièrement importants de l'invention comprennent des constructions nucléotidiques qui se répliquent en culture tissulaire et dans un porc hôte. L'invention concerne également de nouveaux génomes de VDEP de pleine longueur qui peuvent se répliquer efficacement dans des animaux hôtes et en culture tissulaire.