1-(ARYL)-3-(HETEROARYL) UREA COMPOUNDS AND THEIR USE AS OLIG2 INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Ol...

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Bibliographische Detailangaben
Hauptverfasser:	MCHARDY, STANTON F, WANG, HUA-YU LEO, LOPEZ, AMBROSIO, CAMPOS, BISMARCK, TUCCI, FABIO C, BEATON, GRAHAM, RAVULA, SATHEESH B, RUIZ, FRANCISCO XAVIER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma. Described herein are compounds having the structure of Formula (IIA): L'invention concerne des composés et des compositions pharmaceutiques contenant lesdits composés, qui inhibent l'activité d'Olig2. L'invention concerne également des méthodes d'utilisation desdits inhibiteurs d'Olig2, seuls et en combinaison avec d'autres composés, pour traiter le cancer et d'autres maladies. Les inhibiteurs d'Olig 2 peuvent en particulier être utilisés pour traiter le glioblastome.