ANTI-AMYLOID COMPOUNDS CONTAINING BENZOFURAZAN

In general, among other things, disclosed herein are compounds of Formula I: or pharmaceutically acceptable salts thereof, in which: Rii is, e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N1,N1,N3-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, or 3-(morpholin-1-ylmethyl)azetidin-1-yl; R13 is, e.g., phenyl optionally substituted with one or more substituents; and R12 and R14 are each independently hydrogen or alkyl. Pharmaceutical compositions and the use as anti-amyloid compounds are also provided. De manière générale, entre autres choses, des composés de formule 1 sont décrits : ou des sels acceptables sur le plan pharmaceutique, dans lesquels : R11 est, p. ex., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N1, N1, N3-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, ou 3-(morpholin-1-ylmethyl)azetidin-1-yl; R13 est, p. ex., du phényle facultativement substitué par un ou plusieurs substituts; et R12 et R14 sont chacun indépendamment de l'hydrogène ou de l'alkyle. Des compositions pharmaceutiques et l'utilisation comme composés anti-amyloïde sont aussi décrites.