PROCESS IN WATER FOR THE PREPARATION OF BUTYRIC ESTERS OF HYALURONIC ACID SODIUM SALT

The present invention relates to a process for the preparation of hyaluronic acid butyrate, or a salt thereof,acceptable for pharmaceutical or cosmetic use or as a medical device, comprising reacting hyaluronic acid, salified with sodium or another alkali metal, in aqueous solution with butyryl-imid...

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Bibliographische Detailangaben
Hauptverfasser:	SECHI, ALESSANDRA, STUCCHI, LUCA, GIANNI, RITA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DERIVATIVES THEREOF DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention relates to a process for the preparation of hyaluronic acid butyrate, or a salt thereof,acceptable for pharmaceutical or cosmetic use or as a medical device, comprising reacting hyaluronic acid, salified with sodium or another alkali metal, in aqueous solution with butyryl-imidazolide in the presence of sodium carbonate. The present invention also relates to pharmaceutical formulations, cosmetic formulations or medical devices containing the hyaluronic acid sodium salt (HA) butyric esters produced by said process. Cette invention concerne un procédé de préparation de butyrate d'acide hyaluronique, ou un sel de celui-ci, acceptable pour un usage pharmaceutique ou cosmétique ou à titre de dispositif médical, comprenant la réaction d'un acide hyaluronique, salifié avec du sodium ou autre métal alcalin, en solution aqueuse avec un butyryl-imidazolide en présence de carbonate de sodium. Des formulations pharmaceutiques, des formulations cosmétiques ou des dispositifs médicaux contenant les esters butyriques de sel de sodium d'acide hyaluronique (HA) produits par ledit procédé sont en outre décrits.