PROCESSES FOR PREPARING ASK1 INHIBITORS

PROCESSES FOR PREPARING ASK1 INHIBITORS

The present disclosure provides processes for the preparation of a compound of formula (A) which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The di...

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Bibliographische Detailangaben
Hauptverfasser: SARMA, KESHAB, REYNOLDS, TROY EVAN, SILER, DAVID ALLEN, GRIGGS, NOLAN, HEUMANN, LARS V, CHAN, BRENDA J. BURKE, THOMPSON, ANDREW S, BROWN, BRANDON HEATH, NOTTE, GREGORY, LATHROP, STEPHEN P, CHIU, ANNA, WANG, TAO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present disclosure provides processes for the preparation of a compound of formula (A) which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates. La présente invention concerne des procédés de préparation d'un composé de formule (A) qui possède une activité inhibitrice de la kinase régulant le signal apoptotique ("ASK1") et est donc utile dans le traitement de maladies telles que la néphropathie, la néphropathie diabétique et la fibrose rénale. L'invention concerne également des composés qui sont des intermédiaires de synthèse.