METHODS OF MACROMOLECULAR ANALYSIS USING NANOCHANNEL ARRAYS

Abstract Provided herein, in some embodiments, are devices that address the need for efficient determination of the sizes and composition of DNA or other macromolecules by linearizing and analyzing such molecules. Devices for analyzing features such as the physical size of macromolecules or biomarke...

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Hauptverfasser:	DESHPANDE, PARIKSHIT A, BOYCE-JACINO, MICHAEL, CAO, HAN, AUSTIN, MICHAEL D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NANOTECHNOLOGY PERFORMING OPERATIONS PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SPIRITS TESTING TRANSPORTING VINEGAR WINE
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Zusammenfassung:	Abstract Provided herein, in some embodiments, are devices that address the need for efficient determination of the sizes and composition of DNA or other macromolecules by linearizing and analyzing such molecules. Devices for analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules are disclosed. In some embodiments, the devices can perform such high throughput analysis in a massively parallel fashion. In some embodiments, the devices disclosed herein advantageously enable a minimal amount of sample to be used. Date Recue/Date Received 2020-06-15 Abrégé Il est décrit, dans certains modes de réalisation, des dispositifs qui répondent au besoin de déterminer les tailles et la composition de lADN ou dautres macromolécules en linéarisant et en analysant ces molécules. Les dispositifs permettant danalyser les caractéristiques comme la taille physique des macromolécules ou des biomarqueurs le long de grandes molécules dADN génomiques sont décrits. Dans certains modes de réalisation, les dispositifs peuvent effectuer cette analyse à rendement élevé dune manière massivement parallèle. Dans certains modes de réalisation, les dispositifs décrits ont pour avantage de permettre lutilisation dune quantité minimale déchantillons. Date reçue/Date Received 2020-06-15