NOVEL METHYL-PIPERIDINE COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1

NOVEL METHYL-PIPERIDINE COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1

(see formula 1) The present invention provides compounds of Fonnula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KUKLISH, STEVEN LEE, PARTRIDGE, KATHERINE MARIE, MANNINEN, PETER RUDOLPH, WARSHAWSKY, ALAN M, FISHER, MATTHEW JOSEPH, YORK, JEREMY SCHULENBURG, SCHIFFLER, MATTHEW ALLEN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:(see formula 1) The present invention provides compounds of Fonnula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis. La présente invention concerne des composés de formule (1), ou un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle R, R1 et G sont tels que décrits dans la description ; des procédés de préparation desdits composés et l'utilisation de ces composés pour traiter la douleur et/ou l'inflammation associée à l'arthrite ou l'ostéoarthrite.