AMINOPYRIDYLOXYPYRAZOLE COMPOUNDS

The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFpRI), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepa...

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Bibliographische Detailangaben
Hauptverfasser:	JOSEPH, SAJAN, PEI, HUAXING, WOLFANGEL, CRAIG D, ZHAO, GAIYING, MCMILLEN, WILLIAM T, SAWYER, JASON SCOTT, BEIGHT, DOUGLAS W, PARTHASARATHY, SARAVANAN, COATES, DAVID A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFpRI), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease. La présente invention concerne de nouveaux composés d'aminopyridyloxypyrazole qui inhibent l'activité du récepteur 1 du facteur de croissance transformant bêta (TGFpRI), des compositions pharmaceutiques comprenant les composés et des procédés d'utilisation des composés pour traiter le cancer, de préférence cancer du côlon, mélanome, carcinome hépatocellulaire, cancer rénal, glioblastome, cancer du pancréas, syndrome myélodysplasique, cancer du poumon et cancer gastrique et/ou la fibrose, de préférence cirrhose du foie et maladie rénale chronique.