NOVEL FORMULATIONS OF A BRUTON'S TYROSINE KINASE INHIBITOR

Described herein is the Brutons tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, a...

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Bibliographische Detailangaben
Hauptverfasser:	SHU, CASSANDRA, HULVAT, JAMES FRANCIS, TAY, PEARL SHWEO, MINIKIS, RYAN MITCHELL, KUEHL, ROBERT, MCVEY, ALEXANDER JACOB, ATLURI, HARISHA, CHONG, CHING WAH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Described herein is the Brutons tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. La présente invention concerne l'inhibiteur de la tyrosine kinase de Bruton (Btk) qu'est la 1-((R)-3-(4-amino-3- (4-phénoxyphényl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pipéridin-1-yl)prop-2-én-1-one, ainsi que de nouvelles formulations pharmaceutiques de ce composé. L'invention concerne également des compositions pharmaceutiques contenant cet inhibiteur de la Btk, ainsi que des procédés d'utilisation de cet inhibiteur de la Btk, seul ou en association avec d'autres agents thérapeutiques, en vue du traitement de maladies ou d'affections auto-immunes ou hétéro-immunes, du cancer, y compris le lymphome, et de maladies ou d'affections inflammatoires.