NOVEL VACCINE COMPOSITIONS FOR PORCINE EPIDEMIC DIARRHEA VIRUS AND PORCINE DELTACORONAVIRUS

The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), a...

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Hauptverfasser: PLAJA DILME, LAIA, BALASCH SANUY, MONICA, ROMERO GALINDO, OSCAR, DOMINOWSKI, PAUL J, CABANA SUMSI, MARTA, RAPP GABRIELSON, VICKI JON, URNIZA HOSTENCH, ALICIA, MARX, JACQUELINE GAYLE, HARDHAM, JOHN MORGAN
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creator PLAJA DILME, LAIA
BALASCH SANUY, MONICA
ROMERO GALINDO, OSCAR
DOMINOWSKI, PAUL J
CABANA SUMSI, MARTA
RAPP GABRIELSON, VICKI JON
URNIZA HOSTENCH, ALICIA
MARX, JACQUELINE GAYLE
HARDHAM, JOHN MORGAN
description The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate. La présente invention se rapporte à de nouvelles compositions immunogènes protégeant le porc de la maladie causée par le virus de la diarrhée épidémique porcine (PEDV). La présente invention concerne également de nouvelles compositions immunogènes protégeant le porc de la maladie causée par le deltacoronavirus porcin (PDCoV), administrées seules ou en tant que vaccin combiné pour protéger l'animal contre le virus PEDV. Les compositions de l'invention produisent des virus tués dont l'efficacité est améliorée par la sélection d'adjuvants préférés. De nouvelles méthodes de culture sont également utilisées pour augmenter le rendement reproductible des virus en culture. L'invention concerne également des vaccins vivants provenant de l'isolat Calaf14 de PEDV.
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The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate. La présente invention se rapporte à de nouvelles compositions immunogènes protégeant le porc de la maladie causée par le virus de la diarrhée épidémique porcine (PEDV). La présente invention concerne également de nouvelles compositions immunogènes protégeant le porc de la maladie causée par le deltacoronavirus porcin (PDCoV), administrées seules ou en tant que vaccin combiné pour protéger l'animal contre le virus PEDV. 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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
title NOVEL VACCINE COMPOSITIONS FOR PORCINE EPIDEMIC DIARRHEA VIRUS AND PORCINE DELTACORONAVIRUS
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