NOVEL VACCINE COMPOSITIONS FOR PORCINE EPIDEMIC DIARRHEA VIRUS AND PORCINE DELTACORONAVIRUS

The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), a...

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Bibliographische Detailangaben
Hauptverfasser:	PLAJA DILME, LAIA, BALASCH SANUY, MONICA, ROMERO GALINDO, OSCAR, DOMINOWSKI, PAUL J, CABANA SUMSI, MARTA, RAPP GABRIELSON, VICKI JON, URNIZA HOSTENCH, ALICIA, MARX, JACQUELINE GAYLE, HARDHAM, JOHN MORGAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate. La présente invention se rapporte à de nouvelles compositions immunogènes protégeant le porc de la maladie causée par le virus de la diarrhée épidémique porcine (PEDV). La présente invention concerne également de nouvelles compositions immunogènes protégeant le porc de la maladie causée par le deltacoronavirus porcin (PDCoV), administrées seules ou en tant que vaccin combiné pour protéger l'animal contre le virus PEDV. Les compositions de l'invention produisent des virus tués dont l'efficacité est améliorée par la sélection d'adjuvants préférés. De nouvelles méthodes de culture sont également utilisées pour augmenter le rendement reproductible des virus en culture. L'invention concerne également des vaccins vivants provenant de l'isolat Calaf14 de PEDV.