MNK INHIBITORS AND METHODS RELATED THERETO

The present invention relates to compounds according to Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4a, R4b, R5, R6, R7, R8, W1, W2, Y and n are as defined herein. Also described are pharmaceutically acceptable compositions of Formula (I...

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Bibliographische Detailangaben
Hauptverfasser:	REICH, SIEGFRIED H, ERNST, JUSTIN THOMAS, SPRENGELER, PAUL A, XIANG, ALAN XIN, WEBBER, STEPHEN E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds according to Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4a, R4b, R5, R6, R7, R8, W1, W2, Y and n are as defined herein. Also described are pharmaceutically acceptable compositions of Formula (I) compounds as well as methods for utilizing the compounds of Formula (I) and the pharmaceutically acceptable compositions of Formula (I) compounds as inhibitors of Mnk as well as therapeutics for the treatment of diseases such as cancer. La présente invention concerne des composés selon la formule (I) ou un stéréoisomère, un tautomère ou un sel pharmaceutiquement acceptable correspondants, dans laquelle R1, R2, R3, R4a, R4b, R5, R6, R7, R8, W1, W2, Y et n sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiquement acceptables de composés de formule (I) ainsi que des procédés pour utiliser les composés de formule (I) et les compositions pharmaceutiquement acceptables de composés de formule (I) en tant qu'inhibiteurs de Mnk ainsi que comme agents thérapeutiques pour le traitement de maladies telles que le cancer.