HETEROARYL COMPOUNDS FOR KINASE INHIBITION

HETEROARYL COMPOUNDS FOR KINASE INHIBITION

Compounds of Formula Bf, pharmaceutical compositions comprising same, uses thereof for modulating kinase activity, including mutant EGFR and mutant HER2 kinase activity, and uses thereof for treating diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activ...

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Bibliographische Detailangaben
Hauptverfasser: SHAKESPEARE, WILLIAM C, BENCIVENGA, NICHOLAS E, YOUNGSAYE, WILLMEN, LI, FENG, GONG, YONGJIN, ZHOU, TIANJUN, WEST, ANGELA V, THOMAS, RANNY M, ZHU, XIAOTIAN, HUANG, WEI-SHENG, KOHLMANN, ANNA, ZHANG, YUN, DALGARNO, DAVID C
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Compounds of Formula Bf, pharmaceutical compositions comprising same, uses thereof for modulating kinase activity, including mutant EGFR and mutant HER2 kinase activity, and uses thereof for treating diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein: (formula Bf) Des composés de formule Bf, des compositions pharmaceutiques les comprenant, des utilisations connexes pour moduler l'activité de kinase, y compris l'activité de kinase EGFR mutante et HER2 mutante et des utilisations connexes pour traiter des maladies et des conditions associées à l'activité de kinase, y compris de la kinase EGFR mutante et HER2 mutante, sont décrits :