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Provided herein are compositions and methods for generating an immunogenic response in humans. Such compositions include an immunogenic biological agent encompassed by (ii) an agent that directs delivery of the immunogenic biological agent to the ileum of the human, wherein agent (ii) is an enteric...

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Bibliographische Detailangaben
Hauptverfasser:	TRAGER, GEORGE, TUCKER, SEAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compositions and methods for generating an immunogenic response in humans. Such compositions include an immunogenic biological agent encompassed by (ii) an agent that directs delivery of the immunogenic biological agent to the ileum of the human, wherein agent (ii) is an enteric coating (e.g., Eudragit®) that has a threshold pH 5.8-6.8. Further provided are methods for designing such compositions, e.g., for vaccines. L'invention concerne des compositions et des procédés pour générer une réponse immunogénique chez les humains. Ces compositions comprennent un agent biologique immunogénique revêtu (ii) d'un agent qui dirige l'administration de l'agent biologique immunogénique vers l'iléon de l'humain, l'agent (ii) étant un enrobage gastro-résistant (p.ex Eudragit®) qui a un pH seuil de 5,8 à 6,8. L'invention concerne en outre des procédés pour la conception de ces compositions, p.ex. pour des vaccins.