THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME

THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME

The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. La présente invention porte d'une manière général...

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Bibliographische Detailangaben
Hauptverfasser: WANG, HONG, DEWITT, DAVID, SONG, YOUNG-HO, FIGUEIREDO, MARIA, TROIANO, GREG, PEEKE, ERICK, VAN GEEN HOVEN, CHRISTINA, WRIGHT, JAMES
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. La présente invention porte d'une manière générale sur des nanoparticules comprenant un acide essentiellement hydrophobe, un agent thérapeutique basique possédant un azote protonable, et un polymère. D'autres aspects concernent des procédés de fabrication et d'utilisation de telles nanoparticules.