SIRP-ALPHA VARIANT CONSTRUCTS AND USES THEREOF

The invention relates to compositions and methods of SIRP-a variant constructs including SIRP-.alpha. variants. The SIRP-.alpha. variant constructs may be engineered in a variety of ways to respond to environmental factors, such as pH, hypoxia, and/or the presence of tumor- associated enzymes or tum...

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Bibliographische Detailangaben
Hauptverfasser:	SIM, BANG JANET, GOODMAN, COREY, PONS, JAUME, VRLJIC, MARIJA, DEMING, LAURA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to compositions and methods of SIRP-a variant constructs including SIRP-.alpha. variants. The SIRP-.alpha. variant constructs may be engineered in a variety of ways to respond to environmental factors, such as pH, hypoxia, and/or the presence of tumor- associated enzymes or tumor-associated antigens. The SIRP-.alpha. variant constructs of the invention may be used to treat various diseases, such as cancer, preferably solid tumor or hematological cancer. La présente invention concerne des compositions et des méthodes relatives à des constructions de variants SIRP-a. Les constructions de variants SIRP-a peuvent modifiées de diverses façons pour répondre à des facteurs environnementaux, comme le pH, lhypoxie et/ou la présence d'enzymes associées à une tumeur ou d'antigènes associés à une tumeur. Les constructions selon l'invention peuvent être utilisées pour traiter diverses maladies, comme le cancer, de préférence une tumeur solide ou un cancer hématologique.