CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclo...
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| creator | WELLS, JAMES A RENSLO, ADAM R LAUTERWASSER, ERICA M.W FONTAINE, SHAUN D SPANGLER, BENJAMIN B |
| description | Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.
L'invention concerne, inter alia, des compositions de promédicaments et des procédés d'utilisation de celles-ci pour le traitement et la détection d'une maladie. Plus spécifiquement, l'invention porte sur un composé de formule (I) comportant des cycles pipéridine et 1,2,4-trioxolane spiro-fusionnés, à savoir du 1,2,4-trioxa- 8-azaspiro[4.5] décane. L'invention concerne également une composition pharmaceutique contenant le composé et un support pharmaceutiquement acceptable. |
| format | Patent |
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L'invention concerne, inter alia, des compositions de promédicaments et des procédés d'utilisation de celles-ci pour le traitement et la détection d'une maladie. Plus spécifiquement, l'invention porte sur un composé de formule (I) comportant des cycles pipéridine et 1,2,4-trioxolane spiro-fusionnés, à savoir du 1,2,4-trioxa- 8-azaspiro[4.5] décane. L'invention concerne également une composition pharmaceutique contenant le composé et un support pharmaceutiquement acceptable.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; TESTING</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230207&DB=EPODOC&CC=CA&NR=2937752C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230207&DB=EPODOC&CC=CA&NR=2937752C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WELLS, JAMES A</creatorcontrib><creatorcontrib>RENSLO, ADAM R</creatorcontrib><creatorcontrib>LAUTERWASSER, ERICA M.W</creatorcontrib><creatorcontrib>FONTAINE, SHAUN D</creatorcontrib><creatorcontrib>SPANGLER, BENJAMIN B</creatorcontrib><title>CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS</title><description>Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.
L'invention concerne, inter alia, des compositions de promédicaments et des procédés d'utilisation de celles-ci pour le traitement et la détection d'une maladie. Plus spécifiquement, l'invention porte sur un composé de formule (I) comportant des cycles pipéridine et 1,2,4-trioxolane spiro-fusionnés, à savoir du 1,2,4-trioxa- 8-azaspiro[4.5] décane. L'invention concerne également une composition pharmaceutique contenant le composé et un support pharmaceutiquement acceptable.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB1jnT28XRWCHAN8o_wdHENVnAMVggI8ncJCnUPVnDzD1IIdvVxdQ7xDHNVcHH1AVJBkQr-bgqO7q5-IcE8DKxpiTnFqbxQmptB3s01xNlDN7UgPz61uCAxOTUvtSTe2dHI0tjc3NTI2ZiwCgCTLykK</recordid><startdate>20230207</startdate><enddate>20230207</enddate><creator>WELLS, JAMES A</creator><creator>RENSLO, ADAM R</creator><creator>LAUTERWASSER, ERICA M.W</creator><creator>FONTAINE, SHAUN D</creator><creator>SPANGLER, BENJAMIN B</creator><scope>EVB</scope></search><sort><creationdate>20230207</creationdate><title>CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS</title><author>WELLS, JAMES A ; RENSLO, ADAM R ; LAUTERWASSER, ERICA M.W ; FONTAINE, SHAUN D ; SPANGLER, BENJAMIN B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2937752C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>WELLS, JAMES A</creatorcontrib><creatorcontrib>RENSLO, ADAM R</creatorcontrib><creatorcontrib>LAUTERWASSER, ERICA M.W</creatorcontrib><creatorcontrib>FONTAINE, SHAUN D</creatorcontrib><creatorcontrib>SPANGLER, BENJAMIN B</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WELLS, JAMES A</au><au>RENSLO, ADAM R</au><au>LAUTERWASSER, ERICA M.W</au><au>FONTAINE, SHAUN D</au><au>SPANGLER, BENJAMIN B</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS</title><date>2023-02-07</date><risdate>2023</risdate><abstract>Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.
L'invention concerne, inter alia, des compositions de promédicaments et des procédés d'utilisation de celles-ci pour le traitement et la détection d'une maladie. Plus spécifiquement, l'invention porte sur un composé de formule (I) comportant des cycles pipéridine et 1,2,4-trioxolane spiro-fusionnés, à savoir du 1,2,4-trioxa- 8-azaspiro[4.5] décane. L'invention concerne également une composition pharmaceutique contenant le composé et un support pharmaceutiquement acceptable.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING |
| title | CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS |
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