ONE POT SYNTHESIS OF TETRAZOLE DERIVATIVES OF SIROLIMUS

A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale that improves currently available syntheses. In one embodiment, dried rapamycin is dissolved in isopropylacetate. After cooling and 2,6-Lutidine addition, triflic anhydride is slowly added at -30°C. S...

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Hauptverfasser:	BURKAR, SANJAY, BONK, PETER, PATEL, SUBHASH, CHEN, YONG, HSIAO, CHI-NUNG, DHAON, MADHUP
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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