1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by formula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic...

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Hauptverfasser: ZHANG, HAONAN, CHEN, KAIXIAN, ZHENG, YONGTANG, YANG, LIUMENG, XIE, XIN, PENG, PANFENG, LIU, HONG, WU, BEILI, ZHU, YA, ZHOU, YU, JIANG, HUALIANG, LI, JIAN, LUO, RONGHUA, CHEN, YING, LI, JING
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by formula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection. L'invention concerne des composés d'amine cyclique substitués en 1-(3-aminopropyl) tels que représentés par la formule (I), des sels pharmaceutiquement acceptables, des énantiomères, diastéréoisomères, leurs racémates et mélanges, et un procédé synthétique de ces composés d'amine cyclique substitués en 1-(3-aminopropyl) à l'aide de formaldéhyde hétérocyclique aromatique en tant que matière brute. Ces composés peuvent être utilisés comme antagoniste de CCR 5 pour le traitement de l'infection du VIH.