FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof, including a compound represented by formula (IIA), or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, bein...

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Bibliographische Detailangaben
Hauptverfasser:	HEINELT, UWE, DELIGNY, MICHAEL, MAC COSS, MALCOLM, CALMIANO, MARK DANIEL, HEER, JAG PAUL, JACKSON, VICTORIA ELIZABETH, SWINNEN, DOMINIQUE LOUIS LEON, ALEXANDER, RIKKI PETER, GALLIMORE, ELLEN OLIVIA, SABNIS, YOGESH ANIL, QUINCEY, JOANNA RACHEL, CHOVATIA, PRAFUL TULSHI, BROWN, JULIEN ALISTAIR, ZHU, ZHAONING, WEHNER, VOLMAR, KROEPLIEN, BORIS, BRACE, GARETH NEIL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof, including a compound represented by formula (IIA), or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. La présente invention concerne une série de dérivés d'imidazole tricyclique condensé, en particulier des dérivés de dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine, et leurs analogues, des modulateurs puissants de l'activité du TNF-alpha humain, qui sont donc utiles dans le traitement et/ou la prévention de diverses maladies humaines, notamment les troubles auto-immuns et inflammatoires, les troubles neurologiques et neurodégénératifs, les troubles nociceptifs et de la douleur, les troubles cardiovasculaires, les troubles métaboliques, les troubles oculaires et les troubles oncoloqigues.