FUSED 5-MEMBERED HETEROARYL-IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof: , such as a compound of formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: , being potent mo...
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| creator | JACKSON, VICTORIA ELIZABETH BROWN, JULIEN ALISTAIR ALI, MEZHER HUSSEIN ALEXANDER, RIKKI PETER |
| description | Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof: , such as a compound of formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: , being potent modulators of human TNFct activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Cette invention concerne une série de dérivés d'imidazo[2,1-b]thiazole substitués, et d'analogues de ceux-ci, qui sont de puissants modulateurs de l'activité du TNFa humain, et sont par conséquent avantageux dans le traitement et/ou la prévention de diverses maladies humaines, comprenant les troubles auto-immuns et inflammatoires; les troubles neurologiques et neurodégénératifs; la douleur et les troubles nociceptifs; les troubles cardiovasculaires; les troubles métaboliques; les troubles oculaires; et les troubles oncologiques. |
| format | Patent |
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Cette invention concerne une série de dérivés d'imidazo[2,1-b]thiazole substitués, et d'analogues de ceux-ci, qui sont de puissants modulateurs de l'activité du TNFa humain, et sont par conséquent avantageux dans le traitement et/ou la prévention de diverses maladies humaines, comprenant les troubles auto-immuns et inflammatoires; les troubles neurologiques et neurodégénératifs; la douleur et les troubles nociceptifs; les troubles cardiovasculaires; les troubles métaboliques; les troubles oculaires; et les troubles oncologiques.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211026&DB=EPODOC&CC=CA&NR=2930912C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211026&DB=EPODOC&CC=CA&NR=2930912C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JACKSON, VICTORIA ELIZABETH</creatorcontrib><creatorcontrib>BROWN, JULIEN ALISTAIR</creatorcontrib><creatorcontrib>ALI, MEZHER HUSSEIN</creatorcontrib><creatorcontrib>ALEXANDER, RIKKI PETER</creatorcontrib><title>FUSED 5-MEMBERED HETEROARYL-IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY</title><description>Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof: , such as a compound of formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: , being potent modulators of human TNFct activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Cette invention concerne une série de dérivés d'imidazo[2,1-b]thiazole substitués, et d'analogues de ceux-ci, qui sont de puissants modulateurs de l'activité du TNFa humain, et sont par conséquent avantageux dans le traitement et/ou la prévention de diverses maladies humaines, comprenant les troubles auto-immuns et inflammatoires; les troubles neurologiques et neurodégénératifs; la douleur et les troubles nociceptifs; les troubles cardiovasculaires; les troubles métaboliques; les troubles oculaires; et les troubles oncologiques.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB3Cw12dVEw1fV19XVyDQIyPVxDXIP8HYMifXQ9fT1dHKP8fVwVXFyDPMMcQzzDXIMVHIMVfP1dQn0cQ_yDghX83RRC_NwUHJ2Bkp4hkTwMrGmJOcWpvFCam0HezTXE2UM3tSA_PrW4IDE5NS-1JN7Z0cjS2MDS0MjZmLAKAJekLgI</recordid><startdate>20211026</startdate><enddate>20211026</enddate><creator>JACKSON, VICTORIA ELIZABETH</creator><creator>BROWN, JULIEN ALISTAIR</creator><creator>ALI, MEZHER HUSSEIN</creator><creator>ALEXANDER, RIKKI PETER</creator><scope>EVB</scope></search><sort><creationdate>20211026</creationdate><title>FUSED 5-MEMBERED HETEROARYL-IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY</title><author>JACKSON, VICTORIA ELIZABETH ; BROWN, JULIEN ALISTAIR ; ALI, MEZHER HUSSEIN ; ALEXANDER, RIKKI PETER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2930912C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JACKSON, VICTORIA ELIZABETH</creatorcontrib><creatorcontrib>BROWN, JULIEN ALISTAIR</creatorcontrib><creatorcontrib>ALI, MEZHER HUSSEIN</creatorcontrib><creatorcontrib>ALEXANDER, RIKKI PETER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JACKSON, VICTORIA ELIZABETH</au><au>BROWN, JULIEN ALISTAIR</au><au>ALI, MEZHER HUSSEIN</au><au>ALEXANDER, RIKKI PETER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FUSED 5-MEMBERED HETEROARYL-IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY</title><date>2021-10-26</date><risdate>2021</risdate><abstract>Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof: , such as a compound of formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: , being potent modulators of human TNFct activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Cette invention concerne une série de dérivés d'imidazo[2,1-b]thiazole substitués, et d'analogues de ceux-ci, qui sont de puissants modulateurs de l'activité du TNFa humain, et sont par conséquent avantageux dans le traitement et/ou la prévention de diverses maladies humaines, comprenant les troubles auto-immuns et inflammatoires; les troubles neurologiques et neurodégénératifs; la douleur et les troubles nociceptifs; les troubles cardiovasculaires; les troubles métaboliques; les troubles oculaires; et les troubles oncologiques.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FUSED 5-MEMBERED HETEROARYL-IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
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