FUSED 5-MEMBERED HETEROARYL-IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof: , such as a compound of formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: , being potent mo...

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Bibliographische Detailangaben
Hauptverfasser:	JACKSON, VICTORIA ELIZABETH, BROWN, JULIEN ALISTAIR, ALI, MEZHER HUSSEIN, ALEXANDER, RIKKI PETER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of formula (I) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or glucuronide derivatives thereof, or co-crystals thereof: , such as a compound of formula (IIA) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: , being potent modulators of human TNFct activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. Cette invention concerne une série de dérivés d'imidazo[2,1-b]thiazole substitués, et d'analogues de ceux-ci, qui sont de puissants modulateurs de l'activité du TNFa humain, et sont par conséquent avantageux dans le traitement et/ou la prévention de diverses maladies humaines, comprenant les troubles auto-immuns et inflammatoires; les troubles neurologiques et neurodégénératifs; la douleur et les troubles nociceptifs; les troubles cardiovasculaires; les troubles métaboliques; les troubles oculaires; et les troubles oncologiques.