NMDA ANTAGONIST PRODRUGS

Prodrugs of an NMDA antagonist, (S)-1-phenyl-2-(pyridin-2-yl)ethanamine, which may be used in the treatment of depression or pain are provided, such as compounds of formula (I) (see formula I) (see formula above) wherein R1 is C1-6 alkylC(O)O(C1-6 alkoxy) or , and wherein AA is a peptide bond-linked...

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Bibliographische Detailangaben
Hauptverfasser:	NORDVALL, GUNNAR, QUIRK, MICHAEL, BERNSTEIN, PETER ROBERT, MALMBORG, PER JONAS, WEIGELT, DIRK REINHOLD, HOGDIN, KATHARINA, BALESTRA, MICHAEL, KERS, ANNIKA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Prodrugs of an NMDA antagonist, (S)-1-phenyl-2-(pyridin-2-yl)ethanamine, which may be used in the treatment of depression or pain are provided, such as compounds of formula (I) (see formula I) (see formula above) wherein R1 is C1-6 alkylC(O)O(C1-6 alkoxy) or , and wherein AA is a peptide bond-linked natural amino acid; or a pharmaceutically acceptable salt thereof. Promédicaments d'un antagoniste de NMDA, (S) -1-phényl -2-(pyridin-2-yl) éthanamine, utiles pour le traitement de la dépression (en particulier un trouble dépressif majeur) ou de la douleur; compositions les comprenant; et procédés de fabrication de ceux-ci.