METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T

The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arth...

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Bibliographische Detailangaben
Hauptverfasser:	WOODS, CRAIG R, NISHIMURA, RACHEL, KUMMER, DAVID A, CUMMINGS, MAXWELL D, EDWARDS, JAMES P, FOURIE, ANNE, VENKATESAN, HARIHARAN, LEONARD, KRISTI A, MAHAROOF, UMAR, XUE, XIAOHUA, GOLDBERG, STEVEN, WANG, AIHUA, KREUTTER, KEVIN D, WOLIN, RONALD L, JONES, WILLIAM MOORE, BARBAY, KENT, URBANSKI, MAUD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1. La présente invention concerne des composés de formule (I). dans laquelle : R1, R2, R3, R4, R5, R6, R7, R8, et R9 ont la signification indiquée dans la description. L'invention concerne également une méthode qui permet de traiter ou d'atténuer un syndrome, un trouble ou une maladie, ledit syndrome, trouble ou maladie étant la polyarthrite rhumatoïde ou le psoriasis. L'invention concerne également une méthode qui permet de moduler l'activité de ROR?t chez un mammifère par administration d'une quantité thérapeutiquement efficace d'au moins un composé de la revendication 1.