IMPROVED TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT
The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluore...
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Sprache: | eng ; fre |
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Zusammenfassung: | The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.
La présente invention concerne un procédé visant à déterminer une fonction d'organe chez un sujet et comprenant les étapes consistant à : générer une première courbe concentration-heure obtenue par mesure transcutanée dans un fluide biologique, à une première position, de la fluorescence de fond sur au moins une première heure, et la fluorescence d'un composé indicateur sur au moins une deuxième, troisième, quatrième, cinquième et sixième heure ; générer une seconde courbe de concentration obtenue par mesure transcutanée dans un fluide biologique, à une seconde position, de la fluorescence de fond sur au moins une septième heure et la fluorescence d'un composé indicateur sur au moins une huitième, neuvième, dixième, onzième et douzième heure ; insérer la première et la seconde courbe de concentration dans un modèle cinétique repré |
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