PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT

The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions relat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	HOENKE, CHRISTOPH, LESSEL, UTA, SCHMID, BERNHARD, ROSENBROCK, HOLGER, GIOVANNINI, RICCARDO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1). La présente invention concerne des dérivés de pipérazine substitués de formule générale (I) et la préparation desdits composés. Elle concerne également des compositions pharmaceutiques comprenant un composé selon la formule générale (I), et l'utilisation de ces composés pour le traitement de divers états pathologiques associés au transporteur 1 de la glycine (GlyT1).