HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF

The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and phaimaceutically acceptable compositions thereof, useful as BTK inhibitors. In particular, these BTK inhibitors are compounds of formula I, in which Ring A is a 6-membered heteroaryl ring having 1 or 2 nit...

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Hauptverfasser:	LIU-BUJALSKI, LESLEY, NEAGU, CONSTANTIN, JONES, REINALDO, TATE, DEVON, GARDBERG, ANNA, MOCHALKIN, IGOR, JOHNSON, THERESA L, CALDWELL, RICHARD D, QIU, HUI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and phaimaceutically acceptable compositions thereof, useful as BTK inhibitors. In particular, these BTK inhibitors are compounds of formula I, in which Ring A is a 6-membered heteroaryl ring having 1 or 2 nitrogens, selected from pyridine, pyrazine, pyridazine, and pyrimidine. Representative of the inhibitors of the present application is compound 63 shown below. La présente invention concerne des composés pyridine, pyrimidine, pyrazine, et pyridazine, et des compositions pharmaceutiquement acceptables de ceux-ci, utiles en tant qu'inhibiteurs de la BTK.