CHLOROTOXIN CONJUGATES AND METHODS OF USE THEREOF

Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate comp...

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Bibliographische Detailangaben
Hauptverfasser:	JOCHHEIM, CLAUDIA, NAIRN, NATALIE, BYRNES-BLAKE, KELLY, WISS, VALORIE R, STROUD, MARK, HANSEN, STACEY J, MILLER, DENNIS M, NOVAK, JULIA E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided. L'invention concerne des compositions, des formulations et des kits comprenant des composés de conjugué de chlorotoxine, notamment des composés natifs et des variants modifiés de peptide de chlorotoxine conjugués à des molécules reporter comprenant des colorants fluorescents. L'invention concerne des procédés de détection et de traitement de cancers et de tumeurs avec des composés de conjugué de chlorotoxine, notamment des procédés d'imagerie de tissus et de cellules de tumeur. L'invention concerne également des profils posologiques et pharmacocinétiques et des applications diagnostiques employant les composés de conjugué de chlorotoxine.