2,8-DIAZASPIRO[4.5]DECANE AND 3,9-DISPIRO[5.5]UNDECANE DERIVATES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS TRYPTOPHAN HYDROXYLASE INHIBITORS

The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer. The spirocyclic compounds are of the following structure: or a pharmaceutically acceptable salt thereof. La présente invention concerne des composés spirocycliques qui sont des inhibiteurs de la tryptophane hydroxylase (TPH), en particulier de son isoforme 1 (TPH1), qui sont utiles pour le traitement de maladies ou de troubles associés à la sérotonine périphérique, comprenant par exemple les maladies gastro-intestinales, cardiovasculaires, pulmonaires, inflammatoires, métaboliques, et les maladies à faible masse osseuse, ainsi que le syndrome sérotoninergique, et le cancer.