SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND .BETA.2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES

SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND .BETA.2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES

ABSTRACT The present invention is directed to pharmaceutically acceptable crystalline addition salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives of formula (l) or pharmaceutically acceptable solvates thereof: R4 R5 OH 0 V, R6 R1 R2 7 C5 HO HN M R3 0 Formula (l) The provided pha...

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Hauptverfasser: CARRERA CARRERA, FRANCESC, PRAT QUINONES, MARIA, JULIA JANE, MONTSERRAT, PAJUELO LORENZO, FRANCESCA, PUIG DURAN, CARLOS, PEREZ ANDRES, JUAN ANTONIO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:ABSTRACT The present invention is directed to pharmaceutically acceptable crystalline addition salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives of formula (l) or pharmaceutically acceptable solvates thereof: R4 R5 OH 0 V, R6 R1 R2 7 C5 HO HN M R3 0 Formula (l) The provided pharmaceutically acceptable crystalline addition salts are stable, and have relatively high melting point. CPST Doc: 260697.1 Date Recue/Date Received 2020-06-05 La présente invention concerne des sels d'addition cristallins (i) de dérivés 8-hydroxyquinolin- 2(1H)-one et (ii) d'un acide dicarboxylique ou d'un sulfimide, ou des solvates pharmaceutiquement acceptables de ceux-ci.