ANTI-VEGF ANTIBODY AND PHARMACEUTICAL COMPOSITION FOR PREVENTION, DIAGNOSIS OR TREATMENT OF CANCER OR ANGIOGENESIS-RELATED DISEASE CONTAINING THE SAME

The present invention relates to: a novel anti-vascular endothelial growth factor (VEGF) antibody having a strong binding affinity for VEGF and capable of inhibiting in vivo tumor growth; and a composition for the treatment of cancer, containing the same. The antibody of the present invention shows...

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Bibliographische Detailangaben
Hauptverfasser:	SEUNG, WOO JIN, JUNG, EUN-EE, LEE, SUNG-HEE, SONG, DONGSUP, DOH, HYOUNMIE, KIM, YOO-JIN, LEE, DONGSOP, HAN, KYUNG MI, KIM, CHAE YOUNG, KIM, BYONG MOON, KIM, DONG-HYEON, HWANG, KYUSANG, LEE, JINSEOK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to: a novel anti-vascular endothelial growth factor (VEGF) antibody having a strong binding affinity for VEGF and capable of inhibiting in vivo tumor growth; and a composition for the treatment of cancer, containing the same. The antibody of the present invention shows a remarkable binding property to human and mouse VEGF, suppresses the proliferation and permeability of a human umbilical vein endothelial cell (HUVEC) and inhibits tumor growth, and thus can be useful as an antibody for the treatment of cancer. La présente invention porte sur : un nouvel anticorps dirigé contre le facteur de croissance de l'endothélium vasculaire (VEGF) ayant une forte affinité de liaison au VEGF et pouvant inhiber in vivo la croissance tumorale ; et une composition pour le traitement d'un cancer, le contenant. L'anticorps selon la présente invention présente une remarquable propriété de liaison au VEGF humain et de souris, inhibe la prolifération et la perméabilité d'une cellule endothéliale de cordon ombilical humain (HUVEC) et peut supprimer la croissance tumorale, et donc peut être utile comme anticorps pour le traitement d'un cancer.