CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS
Disclosed herein are pharmaceutical compositions comprising a plurality of releasable drug moieties, each drug moiety including at least one carboxylic acid group and at least one hydroxyl group. The drug moieties are covalently attached to each other through the at least one hydroxyl group of one d...
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| Format: | Patent |
| Sprache: | eng ; fre |
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| Zusammenfassung: | Disclosed herein are pharmaceutical compositions comprising a plurality of releasable drug moieties, each drug moiety including at least one carboxylic acid group and at least one hydroxyl group. The drug moieties are covalently attached to each other through the at least one hydroxyl group of one drug moiety and the at least one carboxylic acid group of another drug moiety, thereby forming a polymer. The drug moiety is suitably a prostacyclin. Also provided are therapeutic uses of pharmaceutical compositions, including use for the treatment of pulmonary hypertension. The prostacyclin may be a compound of the Formula (I):
L'invention concerne des composés polymères pour la libération de médicaments, des compositions comprenant des composés prostacyclines de formule (I), et leurs procédés de préparation. Un polymère préféré est composé d'une unité répétitive de structure suivante : |
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