ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS

This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers. La présente invention concerne...

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Bibliographische Detailangaben
Hauptverfasser:	ROMERIL, STUART PAUL, LUENGO, JUAN I, NEWLANDER, KENNETH ALLEN, JOHNSON, NEIL W, BURGESS, JOELLE LORRAINE, KASPAREC, JIRI, SU, DAI-SHI, KNIGHT, STEVEN DAVID, BLACKLEDGE, CHARLES WILLIAM, JR, MILLER, WILLIAM HENRY, LAFRANCE, LOUIS V., III, TIAN, XINRONG, SCHULZ, MARK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers. La présente invention concerne de nouveaux composés de formule (I) qui sont des inhibiteurs de l'activateur de l'homologue 2 de Zeste (EZH2), des compositions pharmaceutiques les contenant, des procédés pour leur préparation, et leur utilisation en thérapie pour le traitement de cancers. (I)