ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF

The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-l-methylpiperidin-4-yl)-4H-chromen-4-ones) analogs of Formula A or a pharmaceutically acceptable salt thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound. The compound of Formula A exhibits inhibition of cyclin-dependent kinase (CDK) which is useful in treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer, etc. wherein: n=1, the dotted line indicates the double bond; R1 is selected from the group consisting of 3-chlorophenyl, anthracen-9-yl, 2-fluorophenyl, 4-chlorophenyl, 2,6-dichlorophenyl, 2,3,4,5,6-pentafluorophenyl and 3-fluorophenyl; and R2, R3 and R4 is hydrogen. La présente invention concerne des analogues de rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-méthylpipéridin-4-yl)-4H-chromén-4-one) de formule A et des sels pharmaceutiquement acceptables de ceux-ci. De plus, l'invention concerne des compositions pharmaceutiquement acceptables comprenant au moins un tel composé, et des procédés d'utilisation des composés pour le traitement ou la prévention de divers troubles prolifératifs tels que le mélanome, la leucémie, le cancer du sein et le cancer de la prostate, etc. [insérer la formule A ici] dans laquelle, n=0 ou 1, la ligne en pointillés indique la double liaison.