CFTR MRNA COMPOSITIONS AND RELATED METHODS AND USES

Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis. La présente invention concerne des matériaux, des compositions...

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Bibliographische Detailangaben
Hauptverfasser:	GUILD, BRAYDON CHARLES, HEARTLEIN, MICHAEL, SMITH, LIANNE, PLANK, CHRISTIAN, DEROSA, FRANK, RUDOLPH, CARSTEN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis. La présente invention concerne des matériaux, des compositions, des procédés de production et des procédés d'administration d'ARNm du gène CFTR en vue de l'induction de l'expression de la protéine CFTR, y compris dans les poumons d'un mammifère. La présente invention se révèle particulièrement utile dans le cadre du traitement de la mucoviscidose.