3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS

The invention provides organic compounds useful as aldosterone synthase inhibitors, having the general formula (l): wherein R1, R2, R3, R4, Rs, Rs, R7, R8, R9, R10, R11, R12, R13, R14, R15, mA , m, n and p are as described herein, compositions including the compounds and use of said compounds for th...

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Bibliographische Detailangaben
Hauptverfasser:	MAERKI, HANS P, MARTIN, RAINER E, TAN, XUEFEI, CHEN, WENMING, AMREIN, KURT, LIU, YONGFU, WANG, LISHA, ZHOU, MINGWEI, AEBI, JOHANNES, HORNSPERGER, BENOIT, KUHN, BERND, MAYWEG, ALEXANDER V
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides organic compounds useful as aldosterone synthase inhibitors, having the general formula (l): wherein R1, R2, R3, R4, Rs, Rs, R7, R8, R9, R10, R11, R12, R13, R14, R15, mA , m, n and p are as described herein, compositions including the compounds and use of said compounds for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism or Cushing syndrome. L'invention concerne de nouveaux composés ayant la formule générale (I), dans laquelle R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, A, m, n et p sont tels que décrits ici, des compositions comprenant les composés et des procédés d'utilisation des composés.