AMIDES AS MODULATORS OF SODIUM CHANNELS

The invention relates to amide compounds of formulae I and I': and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the composit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	JOHNSON, JAMES PHILIP, TERMIN, ANDREAS P, HADIDA-RUAH, SARA SABINA, BEAR, BRIAN RICHARD, ARUMUGAM, VIJAYALAKSMI, ASGIAN, IULIANA LUCI, ANDERSON, COREY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to amide compounds of formulae I and I': and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. L'invention concerne des composés d'amide de la formule I et des sels de qualité pharmaceutique de ceux-ci, utiles comme inhibiteurs des canaux sodiques : (I), (I'). L'invention concerne également des compositions de qualité pharmaceutique comportant les composés de l'invention et des procédés d'utilisation des compositions dans le traitement de divers troubles, comprenant la douleur.