MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME

The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated Lysine compositions. Methods for using such co...

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Bibliographische Detailangaben
Hauptverfasser:	JING, YING, WONG, CHEE FURNG, PEREZ THIELE, MAYDA, ZENG, XIAOBEI, KAYMAKCALAN, ZEHRA, CHUMSAE, CHRISTOPHER, SUBRAMANIAN, KARTIK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated Lysine compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFa is detrimental, are also provided.