THERAPEUTICALLY ACTIVE PYRAZOLO-PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYL-INOSITOL-4-KINASE IIIB (PI4KIIIB) ACTIVITY

THERAPEUTICALLY ACTIVE PYRAZOLO-PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYL-INOSITOL-4-KINASE IIIB (PI4KIIIB) ACTIVITY

A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4- position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral di...

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Bibliographische Detailangaben
Hauptverfasser: HUANG, QIUYA, FORD, DANIEL JAMES, HORSLEY, HELEN TRACEY, GHAWALKAR, ANANT RAMRAO, FRANKLIN, RICHARD JEREMY, VANDERHOYDONCK, BART, REUBERSON, JAMES THOMAS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4- position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseasesand malaria; and organ and cell transplant rejection. Cette invention concerne une série de dérivés de pyrazolo[3,4-d]pyrimidine qui sont substitués à la position 4 par un fragment monocyclique, bicyclique ponté ou spirocyclique de type diaza, qui sont bénéfiques pour traiter et/ou prévenir diverses maladies humaines, comprenant les troubles inflammatoires, autoimmuns et oncologiques ; les maladies virales et le paludisme ; et le rejet de greffes d'organes et de cellules.