N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP

N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP

The present invention relates to disubstituted N-(pyridin-2-yppyrimidin-4-arnine derivatives containing a sulfoximine group of general formula (I): and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or vi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIENAU, PHILIP, SIEMEISTER, GERHARD, BOHLMANN, ROLF, SCHOLZ, ARNE, BOMER, ULF, BOHNKE, NIELS, KOSEMUND, DIRK, LUCKING, ULRICH, ZORN, LUDWIG
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to disubstituted N-(pyridin-2-yppyrimidin-4-arnine derivatives containing a sulfoximine group of general formula (I): and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate coinpounds useful in the preparation of said compounds of general formula (I). L'invention concerne des dérivés de N-(pyridin-2-yl)pyrimidin-4-amines disubstitués contenant un groupe sulfoximine de formule générale (I), comme défini et indiqué dans la description; et des méthodes pour les préparer et les utiliser pour le traitement et/ou la prévention de troubles, en particulier de troubles hyperprolifératifs et/ou de maladies infectieuses d'origine virale et/ou de maladies cardiovasculaires. L'invention concerne également des composés intermédiaires utiles pour la préparation des composés de formule générale (I).