SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS

SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS

Disclosed are substituted tricyclic benzimidazoles compounds as defined herein in formula (I) or pharmaceutically acceptable salts thereof. The compounds of the invention selectively inhibit CDK8 and are therefore useful for treating diseases related to this kinase, especially colorectal and melanom...

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Bibliographische Detailangaben
Hauptverfasser: MILIK, MARIUSZ, GALEZOWSKI, MICHAL, RZYMSKI, TOMASZ, OSOWSKA, KAROLINA, FOGT, JOANNA, WIKLIK, KATARZYNA, CZARDYBON, WOJCIECH, ZAREBSKI, ADRIAN, DREAS, AGNIESZKA, CHOLODY, MAREK, BRZOZKA, KRZYSZTOF, KUCWAJ, KATARZYNA, HORVATH, RAYMOND
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed are substituted tricyclic benzimidazoles compounds as defined herein in formula (I) or pharmaceutically acceptable salts thereof. The compounds of the invention selectively inhibit CDK8 and are therefore useful for treating diseases related to this kinase, especially colorectal and melanoma cancers and other solid and hematological malignancies, autoimmune diseases and inflammatory diseases. Also disclosed are processes for preparing these compounds. La présente invention concerne des composés de type benzimidazoles tricycliques substitués de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci. Les composés selon l'invention inhibent de façon sélective la kinase CDK8 et peuvent donc être utilisés en vue du traitement de maladies associées à ladite kinase et, notamment, le cancer colorectal et le mélanome, de même que d'autres tumeurs malignes solides et hématologiques, les maladies auto-immunes et les maladies inflammatoires. L'invention concerne également des procédés de préparation desdits composés.