ANTIBODIES TO M-CSF

The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof The invention also relates...

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Bibliographische Detailangaben
Hauptverfasser:	LOW, JOSEPH EDWIN, KELLERMANN, SIRID-AIMEE, FOLTZ, IAN, HAAK-FRENDSCHO, MARY, DEVALARAJA, MADHAV NARASIMHA, MOBLEY, JAMES LESLIE, BEDIAN, VAHE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS THEREOF COMPUTING COUNTING CULTURE MEDIA DATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FORADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORYOR FORECASTING PURPOSES ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE,COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTINGPURPOSES, NOT OTHERWISE PROVIDED FOR VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention. La présente invention porte sur des anticorps et des portions de liaison dantigènes associées qui se lient spécifiquement à un M-CSF, préférablement un M-CSF humain, et qui fonctionnent pour inhiber un M-CSF. Linvention porte également sur des anticorps anti-M-CSF et des portions de liaison dantigènes associées. Linvention porte aussi sur des anticorps qui sont des anticorps chimériques, bispécifiques, dérivés, monocaténaires ou des portions de protéines de fusion. Linvention porte également sur des immunoglobulines monocaténaires lourdes et légères isolées dérivées des anticorps anti-M-CSF humains et des molécules dacide nucléique codant de telles immunoglobulines. La présente invention porte également sur des méthodes de fabrication danticorps anti-M-CSF humains, des compositions renfermant ces anticorps et des méthodes employant les anticorps et les compositions servant au diagnostic et au traitement. Linvention fournit également des méthodes de thérapie génique au moyen de molécules dacide nucléique codant les molécules dimmunoglobulines lourdes ou légères qui comportent les anticorps anti-M-CSF humains. Linvention porte également sur des animaux transgéniques et des végétaux transgéniques comportant les molécules dacide nucléique de la présente invention.