IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHOBITORS FOR THE TREATMENT OF CANCER

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related disorders, and liver related disorders. Such compounds are represente...

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Bibliographische Detailangaben
Hauptverfasser:	ROCABOY, CHRISTIAN, BIGNAN, GILLES C, LU, TIANBAO L, CONNOLLY, PETER J, PARKER, MICHAEL H, LUDOVICI, DONALD, MEERPOEL, LIEVEN, SMANS, KARINE, MEYER, CHRISTOPHE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L1, a, b, m, n, R1, R2, R3, R4, and R5 are defined herein. L'invention concerne des composés, des compositions et des méthodes de traitement de diverses maladies, divers syndromes, divers états et divers troubles, comprenant ceux à médiation par l'inhibition de l'enzyme acide gras synthase (FASN), tels que le cancer, l'obésité ou des troubles associés, et des troubles associés au foie. De tels composés sont représentés par la formule (I) telle que suit : où L1, a, b, m, n, R1, R2, R3, R4 et R5 sont définis ici.